Summative effects of vascular risk factors on the progression of Alzheimer's
disease 
   Lead Investigator:    Wei-Ju Lee
   Institution      :    Taichung Veterans General Hospital
   E-Mail           :    winster.lee@hinet.net
   Proposal ID      :    1145



   Proposal Description:
   Vascular risk factors (VRFs) increase the risk of Alzheimer?s disease (AD) and contribute to neurodegenerative processes. VRF-mediated pathophysiology is thought to interact synergistically with cerebral amyloid angiopathy, which affects nutrients inflow and amyloid clearance. However, the impact of VRFs on the progression of AD is still unclear. We hypothesize that more VRFs at baseline would be associated with greater cognitive decline longitudinally across the disease course of AD. The aim of this study is to investigate the      contribution of multiple VRFs on the cognitive decline in AD patients after establishing the diagnosis and the possible interaction between the APOE4 carrier statuses.